Sentence examples for shown to be activating from inspiring English sources

The mutations we have found are clustered and consistent with those shown to be activating mutations in the c-KIT gene of human tumors [ 23].

Her-2 positive tumors have been shown to be composed of two main groups defined by different ER and EGFR status [ 10], and recently Her-2 mutations have been shown to be activating and tumorigenic [ 49] in tumors without DNA amplification of the Her-2 locus.

Thus, autophagy was shown to be activated during cellular senescence, and activation correlated with negative feedback in the PI3K-mTOR pathway.

In fact, at least one cold-triggered amylase activity was shown to be activated as highlighted by zymograms [ 38].

In an independent activation pathway, ATM has been shown to be activated by ATMIN under hypotonic stress which is independent of Nbs1 interactions.

By contrast, intermolecular disulfide formation between Src tyrosine kinase monomers appears to inhibit kinase activity, though Src has also been shown to be activated by H2O2.

The UPR has been shown to be activated during normal epidermal keratinocyte differentiation (37), thus deregulated UPR activity may lead to keratinocyte hyperproliferation.

Depending on the TRPC subtype and the tissue involved, TRPC channels were shown to be activated by a variety of stimuli (including neurotransmitters) or to be constitutively active.

MST1 kinase was shown to be activated under multiple stress conditions, including oxidative stress [ 29] and activation of caspases [ 35, 36].

In addition, astrocytes have been shown to be activated by norepinephrine to enhance the astroglial network response to local neuronal network activity.

In squamous cell carcinoma of the pharynx and larynx, NOTCH1 downstream signaling has been shown to be activated.