Previous studies have shown the implications of poor early response, not only in terms of poor response of core symptoms of schizophrenia, 3, 4, 6, 7 but also in terms of reduced clinician-assessed quality of life, clinician-assessed functioning, patient-reported well-being, clinician-assessed depression, 9 patient-reported functioning, and patients' perceptions of medication benefits.
Previous studies have shown the implication of some PI neurons in the control of the sexual dimorphism, as those neurons have been feminized by the directed expression, in males, of the female version of the sexual determination factor transformer (tra), leading to name those cells "feminizing cells" (FCs) [28], [29].
Cellular models have shown the implication of these antigens in cell adhesion, migration, proliferation and tumour growth.
In any case, earlier studies have shown the implication of other risk factors in the pathogenesis of COPD, including genetic factors, infections, environmental pollution, and occupational exposure [ 22].
Recent studies have shown the implication of hyperglycaemia in the development of HF [ 6], establishing an independent prognostic value for glycated haemoglobin (HbA1c) predicting the risk of HF in both diabetic and non-diabetic patients [ 7, 8].
Besides a strong association of GCA with genes that lie within the major histocompatibility complex (MHC) [ 16- 21], many other studies have shown the implication of genetic variants in key components of immune and inflammatory pathways in GCA susceptibility or clinical expression of this vasculitis [ 21- 34].
In a case study, the process of implementing typical regulations shows the implications of automated working conditions checking in practice.
Finally, we show the implications of dissipativity theory as an appropriate framework to study the nonlinear H^ control problem.
This study shows the implications of the changes of new hazard maps on the design process (i.e., extent of magnification or reduction of the design forces).
Solutions of the model are used to show the implications of these two types of uncertainty for the timing of policy adoption.
We then proceed to show the implications of the mutual dependencies between vehicle and infrastructure and to analyze technical potentials and overall system costs.
