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Regulators have a duty to regulate effectively, but as this research has shown, regulation can create perverse incentives to adhere to rules.
Using a cDNA microarray to examine TGF-β-regulated gene expression in NMuMG cells, we have shown regulation of multiple genes that play important roles in cell cycle control and EMT.
Although a decline of ERα levels is detected in invasive breast cancers, a few studies have shown regulation of cell migration and invasion by ERα [ 20, 21].
This is consistent with studies which have shown regulation of c-myc mRNA by MBP-1 expression and binding to the c-myc P2 promoter in normoxic cells [ 26].
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However, some proteins that spatially regulate mitosis and cytokinesis did show regulation as a group (Fig. 2C).
1. Genes that showed differential regulation between cell-lines and show maximum regulation in at least one of the cell-lines, 2. Genes that showed regulation in the array and are known as TGF-β regulated genes in other studies.
Indeed, the far majority of genes regulated by dietary unsaturated fatty acids in WT mice did not show regulation in PPARα −/− mice, indicating PPARα-dependent regulation.
In addition, 1,099 (33%) genes showed regulation by a specific TF.
It shows regulation as the cause of over $2,000 in additional costs per car during the past decade.
As our essay this week shows, regulation has responded to each crisis by protecting ever more of finance.
Lennon-Dumenil, A. M. et al. Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation.
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