RK-33 has shown potent activity in preclinical cancer models.
Further, PA-AgNPs has shown potent antibacterial effect on E. coli cells.
Twelve of the 20 newly synthesized 4- substituted benzopyrones have shown potent antihistaminic H1 activity.
Specifically, 2,4,5,6-tetrasubstituted dihydropyrimidines have shown potent antimycobacterial activity.
The hepatitis C virus (HCV) NS4B inhibitors have shown potent inhibition of HCV replication in vitro.
Compounds (189, 5, 190) had shown potent anti-trypanosomal activity against Trypanosoma brucei brucei (IC50 0.032, 0.032, 1.33 µM).
Lissoclinotoxins E and F shown potent cytotoxicity towards the MDA-MB-468 (PTEN−/−) and the MDA-MB-435S (PTEN+/+) cell lines.
Previous phytochemical studies have shown potent antioxidant, free radical scavenging, antimutagenic and antigenotoxic activities of flavonoids and phenol isolated from Rhamnus alaternus roots and leaves.
Although bilirubin has shown potent anti-oxidative and anti-inflammatory functions, its clinical applications have been limited due to its insolubility and short half-life.
We have identified inhibitor 4f which has shown potent enzyme inhibitory (Ki = 13 nM) and cellular (IC50 = 21 nM in neuroblastoma cells) assays.
Out of these seven compounds has shown potent inhibitory activity against p38 MAP kinase with IC50 values ranging from 12.97 to 223.5 nM.
