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It was originally produced in the 1750's; the one shown is from a limited 2001 edition.

Example shown is from a 60 dph bird.

The resolution is 2.9 Å and density shown is from a 2Fo Fc electron density map contoured at 1σ. DOI: http://dx.doi.org/10.7554/eLife.03604.019 Of all of the nucleosides and nucleoside analogs studied, the fluorescence probe pyrrolo-cytidine had the strongest binding affinity for vcCNT (KD = 0.9 μM, Figure 5A).

The resolution is 2.8 Å and density shown is from a 2Fo Fc electron density map contoured at 1σ. DOI: http://dx.doi.org/10.7554/eLife.03604.022 10.7554/eLiFigure04.023 Figure 5 figure supplement 2. Water-injected oocytes do not respond to gemcitabine or pyrrolo-gemcitabine treatment.

The resolution is 2.8 Å and density shown is from a 2Fo Fc electron density map contoured at 1σ. DOI: http://dx.doi.org/10.7554/eLife.03604.012 10.7554/eLiFigure04.013 Figure 2 figure supplement 4. Electron density at the nucleoside-binding site of vcCNT-7C8C-5-fluorouridine.

The resolution is 3.1 Å and density shown is from a 2Fo Fc electron density map contoured at 1σ. DOI: http://dx.doi.org/10.7554/eLife.03604.011 10.7554/eLiFigure04.012 figure 2—figure supplement 3. Electron density at the nucleoside-binding site of vcCNT-7C8C-ribavirin.

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Density shown is from an Fo Fc SA-OMIT map contoured at 3σ.

The photomicrograph shown is from an RA ST showing 60%-positive lining cell staining, with the lining layer being composed of macrophages and fibroblasts.

Data shown are from a representative replicate.

The results shown are from a single run, and no other model was fitted.

The data shown are from a representative experiment out of 3-4 differentrialsls producing similar results.

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