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Despite multiple therapeutic approaches for nephrogenic systemic fibrosis (NSF), no single treatment has convincingly shown consistent benefit.
Although intensification of antithrombotic therapy after revascularization has demonstrated benefit in coronary disease populations, this approach has not been well studied or shown consistent benefit in PAD.
Current options for preventing the onset of CAS or valve failure are limited; pharmaceutical approaches such as statins or other drugs may ultimately be useful but have not shown consistent benefit in prior studies [17].
The addition of other agents, such as mitomycin C, doxorubicin or cisplatin, has not shown consistent benefit in terms of either tumour response or survival (Harvey et al, 1984; Taal et al, 1993; Okada et al, 1994).
Mucolytics, alpha trypsin augmentation, leukotriene receptor antagonists, maintenance antibiotic administration, immunoregulators, respiratory stimulants, and vasodilators have either not shown consistent benefit or have an unattractive benefit to risk ratio in patients with COPD (GOLD/WHO/NHLBI 2004; NICE 2004; ATS/ERS 2005).
The aim of haemodynamic support in our sepsis patients was to maintain condiac index at 2.5 l/min per m2 or above because the studies that attempted to maintain a supraphysiologic cardiac index of above 4.0 to 4.5 l/min per m2 have not shown consistent benefit [ 32, 33].
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Protein supplements have not shown consistent benefits on muscle mass and function.
Dual RAS inhibition studies involving aliskiren also have not shown consistent benefits but have reported increased harm with combination treatment.
There is some evidence that the profile of severe or complicated malaria differs between children and adults (WHO 1990), but a review of artemisinin-derivatives in severe malaria has shown consistent benefits in children and adults with only variation in the magnitude of the benefit (Sinclair 2012).
Interestingly, antihypertensive types that have shown consistent benefits in the treatment of hypertension in the very elderly (e.g. ACE-i and diuretics, as in the HYVET trial [ 69, 70]) were not linked with any of our adverse outcomes (i.e. MOH-3, OI, history of faints).
29 Evidence from RCTs and non-randomised comparative studies shows that anti-VEGF therapies show consistent benefit in non-ARMD CNV conditions.
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CEO of Professional Science Editing for Scientists @ prosciediting.com