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Two types of a cross talk between regulons from highly interconnected TRNs are shown as respective page tabs: (i) regulatory cascades (as illustrated for the Shewanella oneidensis TRN in Figure  8), and (ii) co-regulations of genes by multiple regulators.

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Graphic representation of the Michaelis-Menten equation corresponding to the initial velocity of CdPRAC and PaHyPRE as function of substrate concentration is shown, as well as respective Km and Vmax kinetic values (Figure 4A and 4B).

Standard deviations were shown as error bars above respective columns.

The neurotransmitter effects on BMMs from control and CIA animals are shown as percentage of the respective non-stimulated culture.

Significantly elevated activities of caspase-3, caspase-8 and caspase-9 were observed in BJMC3879luc2 cells treated with raloxifene for 24 h and 48 h (data not shown), as compared to the respective controls.

We established background frequency distributions by randomly sampling regions of the same sizes from non-peri-centromeric regions, followed by a targeted search for the respective motif (shown as histograms).

Outlier is shown as a symbol of in their respective group obtained directly from statistical analysis software.

For comparison, analogous measurements on PS NPs were processed in an identical way; the respective values are shown as red triangles in Figure 2. Figure 2 Spectra for silver and polystyrene nanoparticles.

A maximum projection image from the respective movie is shown as inset.

For hsa-dme-sce, the respective numbers are shown as Venn diagrams in Additional File 1, Figure S4.

The change in estimate for each metal exposure variable by including the two other respective metals is shown as supplementary material (See Additional file 1: Figure S2).

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