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Perhaps, we can speculate that the residues BbpThr582 and Leu584 are only involved in the binding with the peptide, but not showing specificities on ligand recognition.
Similar(59)
Recently, sulfonamide based carbonic anhydrase inhibitors (CAI) showing specificity for CA IX have been designed.
A phylogenetic tree of the 92 characterised GH43 enzymes displayed five distinct groups (I − V) showing specificity differences.
This may reflect differential affinity of BT10, showing specificity for RAR and not RXR sub-types.
(C ) Representative histogram showing specificity of CD43 for plasma cells/plasmablasts.
The signal appears clear in WT extracts and absent in Fmr1 KO extracts, showing specificity.
(29) In addition, a scrambled peptide exhibited resistance to HNE cleavage showing specificity of the other substrates.
Our data supports previous biochemical data showing specificity at the level of the Mcl-1-Bak interaction.
A positive ANCA titre was subsequently detected with granular cytoplasmic staining showing specificity for proteinase-3 (55 U/mL).
Historical controls have shown specificities ranging between 84% and 100% [ 18, 29, 30].
Different agglutination kits show specificities of 91.3% to 100% if applied to MRSA colony material [ 30– 30].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com