In this example, new drugs may be just as effective and perhaps even safer without showing efficacy in traditional tests.
Recent interventions have demonstrated promising success, showing efficacy of action in the realm of physics education, and gesture in mathematics and the geosciences.
Topiramate and sodium valproate should be preferred based on the greater availability of data showing efficacy, but they are not free from adverse events.
Glutamate theories and findings from studies showing efficacy of sarcosine, an endogenous, non-selective glycine-reuptake inhibitor mediated by GlyT1, offer an alternative approach.
Compound 30 is a highly potent thrombin receptor antagonist (IC50 = 6.3 nM), a related compound 36 showing efficacy in a monkey ex vivo study.
Previously, we reported potent and selective SGLT1 inhibitors 1 and 2 showing efficacy in oral carbohydrate tolerance tests in diabetic rat models.
In 2009, the literature search identified RCT's showing efficacy shortening symptoms of acute bronchitis for two herbal combinations [17, 18] graded as moderate evidence leading to a strong recommendation for treatment of acute bronchitis with the proven combinations.
Scientists are excited over what they see as a possible breakthrough in the treatment of schizophrenia: the first human trials showing efficacy for a completely new class of antipsychotic drugs.
The Awake@Intel program, for example, is a formal, 10-week program with over 3 years' worth of data showing efficacy across the organization.
There is some good evidence that homeopathic medicines are effective for this common ailment.[16] There have also been several trials showing efficacy of homeopathic treatment for children with ADD/ADHD.[17].
In addition to showing efficacy in the monkey models, the RT inhibitors tenofovir and emtricitabine also showed efficacy in the BLT mouse model against HIV challenge [32].
