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Age and religion/denomination were the only variables showing a consistent direction cross-nationally (Table 2).
Pairs with hazard ratios (HR) showing a consistent direction between HEBCS and POSH data sets and improved significance in the pooled analysis were chosen.
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All DEGs showed a consistent direction of expression change, except for PR Domain Containing 16 (PRDM16) and adrenomedullin (ADM) RNA expression levels, which had inconsistent changes in expression direction.
The third independent signal showed a consistent direction of effect across all four collections (UK-ROI, Finnish, American and Danish) for two intronic SNPs in the TXNRD2 gene.
Differences in kappa that existed across coder characteristics did not show a consistent direction in favor of any particular coder characteristics, see Figure 2.
If the collateral damage associated with a given locus is random, i.e. if there is no hidden bias in the multivariate distribution of damage, the error would not show a consistent direction and would average out at zero.
The effect of completed education reached statistical significance for two conditions, but did not show a consistent direction of effect (the magnitude of the odds ratios was very different across multiple items).
More specifically, 85 of the genes (74%%) showed a consistent direction of expression differences across experiments (i.e. higher in LSB for current experiment and also higher in LSB-like in previous experiment).
The forest plot shows a consistent direction of effect of this allele across all seven samples, which is nominally significant in three of these (Split, Talana and TwinsUK, Table 5).
All results reported as statistically significant have reached our pre-specified, adjusted significance threshold using both Nexus and QuantiSNP results and also shown a consistent direction of effect (frequency difference) using both algorithms.
The chosen SNPs also showed a consistent direction of effect in each of the three case control collections represented by the GENIE Consortium meta-analysed dataset, an international collaboration of three cohorts of type 1 diabetic patients discordant for DN totalling 2916 with nephropathy and 3315 without nephropathy [ 22].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com