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The compound 3 showed potency similar to benznidazole, but lower efficacy.
Results showed potency of multi-targeted drugs of a few compounds from investigated ligand set.
Some of the compounds showed potency in cell-based assays and good pharmacokinetic properties.
Both of them showed potency consistent with pyriminostrobin against larvae and weaker potency than pyriminostrobin against eggs, as shown in Table 50 [50].
Compounds 4 and 11 showed potency toward the intracellular, amastigote stage of L. infantum (IC50 values of 2.1 ± 0.6 and 3.1 ± 1.05 μM, respectively).
Paenibacillin, a recently-discovered lantibiotic from Paenibacillus polymyxa OSY-DF, showed potency against Listeria monocytogenes, methicillin-resistant Staphylococcus aureus and other Gram-positive bacteria.
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Many compounds showed potencies similar to EDTA.
While a strong case can be made for the performance of these features, research has shown potency of color-based and intensity-based features as well.
Our results show that out of 78 compounds, three compounds are worth pursuing as leads, as they show potency of ⩾55% in both cancer cell lines.
Chromatin-modifying compounds that inhibit the activity of histone deacetylases have shown potency as radiosensitizers, but the action of these drugs at a molecular level is not clear.
Mutant 331Δ receptors show increased pEC50 values (∼2 4 fold change from full length) hereby showing potency similar to full length WT.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com