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Levetiracetam showed efficacy comparable with traditionally used anticonvulsants.
Further, Compound 12a showed efficacy in delayed hypersensitivity assay.
Zonisamide is a neuromodulator that has showed efficacy in prevention of CM.
Compounds in this class showed efficacy in human tumor xenograft models.
Mindfulness-based cognitive therapy (MBCT) showed efficacy for currently depressed patients.
Systemic liposomal delivery of a nonviral plasmid DNA showed efficacy in animal models for several cancers.
Only a few compounds showed efficacy in the AG129 DENV mouse model.
Several FLAP inhibitors showed efficacy in early clinical trials in asthma but were not developed commercially for unpublished reasons.
In addition, dichlorobenzoyl derivative 12aa exhibited better oral availability and showed efficacy in an in vivo model after oral administration.
The CGRP receptor antagonists olcegepant (BIBN4096BS) and telcagepant MK-09744) independently showed efficacy in phase III studies for the acute treatment of migraine [3 5].
In this regard, the majority of patients could not have a normal daily planning although the use of symptomatic treatment showed efficacy in pain relief.
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