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Magnetic resonance imaging showed diffusion restriction concerning for ischemia with areas of ring enhancement suggestive of inflammation.
However, the soluble fluconazole loaded gel formulation of CMTC showed diffusion based kinetic model indicating good reservoir for effective application on skin/tissue surfaces.
As expected, all beads showed diffusion coefficient values smaller than water (2.3·10−9 m2/s at 25 °C [31]) due to the presence of trehalose and biopolymers, as well as by the presence of oil (9 × 10−12 m2/s, [32]), which provoked a further reduction of the observed values.
Second, ROI-based analysis was done on the confined areas that showed diffusion restriction.
As shown in Figure 7B, 6 min postadministration and after removal of the skin, the animal receiving free ICG showed diffusion of ICG into the blood (saphenous vein).
Control experiments with CMV (brown line) and 200-nm latex beads (not shown) mixed with TMR-conjugated A38 showed diffusion times identical to those for TMR-labeled A38 alone, indicating no binding to both controls.
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Using high-quality diffusion tensor imaging (DTI) at 3 Tesla, we show diffusion anisotropy in this grey matter area.
The solid component of the tumour can show diffusion restriction.
Epidermoid cysts will distinctively show diffusion restriction on MRI [10].
Diffusion-weighted imaging (DWI) shows diffusion restriction in white matter lesions during the acute phase [17].
Fat suppression MRI is helpful in confirming the dermoid cyst and can show diffusion restriction [9].
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