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Open image in new window Figure 2 Mesp1-null embryos showed defective heart tube formation and looping.
ZmNST3/4-overexpressing Arabidopsis and maize displayed a thickened secondary wall in the stem, and knockdown maize showed defective secondary wall deposition.
NPCs derived in this way from patients carrying a deleterious homoplasmic mutation in the mitochondrial gene MT-ATP6 (m.9185T>C) showed defective ATP production and abnormally high mitochondrial membrane potential (MMP), plus altered calcium homeostasis, which represents a potential cause of neural impairment.
In addition, Fz-4 deficient mice showed defective corpora lutea [42].
In agreement with this notion, Dnmt2 mutant zebrafish showed defective liver, brain and retina development [15].
Surviving Rpn13−/− mice showed defective gametogenesis, delayed growth, high fat accumulation, and altered T-cell development.
The Dlg4 knockout mice showed defective synaptic plasticity and impaired spatial learning [23].
As expected, CFSE-labelled tolerant T cells showed defective expansion when stimulated with pMDM100 peptides.
On the other hand, simulations of sst2Δ (bar1Δ) cells showed defective gradient-induced polarization at 100 nM average α-factor concentration (Fig. 7B).
By examining the morphology of motor neurons in the mutants, we found that some VD neuron axons showed defective morphology in several mutants (Figure 1C and Table 2).
Although ΔLIM showed defective F-actin binding, it accumulated to focal adhesions similar to full-length lasp-2 (Figure 4C, C').
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com