Both NSCs and neurons derived from XPA patient iPSCs showed compromised NER and increased susceptibility to DNA damage-induced apoptosis, which may contribute to XP-associated neurological disorders.
Significantly, SEM of peri-implant bone showed compromised intra-fibrillar collagen mineralization in hyperglycemia, while inter-fibrillar and cement line mineralization remained unaffected.
Active fractions inhibited BrdU incorporation by HDF cells (Fig. 1A, grey histograms) and showed compromised BrdU incorporation between 15.0±8.1 and 41.6±4.0% versus untreated control (100% BrdU incorporation).
Despite the increase in TcBBM-SEs, the new meta-embryos also showed compromised subsequent development.
Additionally, electron microscopy of virions treated with S. nigra extracts showed compromised envelopes and the presence of membrane vesicles.
For example, lac2 showed compromised root elongation under PEG-induced dehydration conditions; lac8 flowered earlier than wild-type plants, and lac15 showed an altered seed color [ 82].
In coronal regions, the ligated complex showed compromised transseptal fiber integrity with decreased birefringence, unlike the observed high birefringence with straight collagen fibers in the control complex.
Significantly, 12% of the population of rejuvenated cells still showed compromised membrane deformability (i.e. membrane displacement less than 80% of baseline).
An Xist allele containing an inversion that includes repeat D (Xist INV ) showed compromised mutant Xist localization and reduced silencing efficiency.
As already observed for the PP1 subunits, Reg1 and Shp1, strains lacking Rts1 (rts1Δ and rts1Δ pph21Δ pph22Δ) showed compromised glucose repression activity although to a more limited extent.
Electron microscopy of virions treated with S. nigra extract showed compromised envelopes and the presence of membrane vesicles, which suggested a mechanism of action.
