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After 60 days post-STZ treatment phase, four of the five mice (M1, M3, M9 and M12) showed a persistent increase in bioluminescent signal.
Furthermore, after exposure to stress imagery, alcoholic patients showed a persistent increase in alcohol craving, subjective distress, and blood pressure responses across multiple time points compared with social drinkers, suggesting an inability to regulate this high alcohol craving and emotional stress state.
Notably, only cells treated with TGF-β showed a persistent increase in the percentage of CD133+ cells, of similar magnitude to the increase observed at day 4. Importantly, only TGF-β exposure was able to induce a significant increase in the expression of CD133 at the transcriptional level in both cell lines (8 and 6 fold increase for Huh7 and HepG2, respectively) (Additional file 5: Figure S3b).
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After the treatments, the groups receiving VAN or low-dose rLys showed a persistent marked increase in WBCs, which were almost restored to the normal range on day 5 after bacterial challenge, whereas the WBC counts in the mice treated with high-dose rLys were even higher, increasing above the normal range.
When pSS patients were compared to patients affected by non-SS sicca syndrome, α-amylases precursor, carbonic anhydrase VI, G3PDH and SPLUNC-2 were still significantly decreased in the former group, while, on the contrary E-FABP, β-2 microglobulin and IGKC protein showed a persistent, significant increase.
Multiple studies have shown that a persistent increase of 0.5 log10 copy per millilitre in the plasma HIV-1 level is associated with a clinically shortened time for progression to AIDS [ 6].
Two of these subjects showed a persistent nephrogram and two did not.
At 5 months, the X-rays showed a persistent fracture gap and the cannulated screws bending.
At 9 months follow-up, the left eye showed a persistent inferior retinal detachment.
As shown in Figure 4D, TBS induced a persistent increase in the amplitude of excitatory postsynaptic currents (EPSCs) that could last during the entire recording period.
For the first time we show that chronic lumbar radicular pain may be associated with a persistent increase of the pro-inflammatory substances IL-6 and IL-8 in serum after disc herniation.
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