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An open-label retrospective chart review of 65 migraine patients who used duloxetine showed a modest decrease in migraine frequency after 2 months, the decrease being most marked in the subgroup with anxiety [76].
Cells exposed to the control buffer showed a modest decrease in the expression of these proteins, possibly due to the lack of amino acids in the buffer.
Brain tissues from Rpn13−/− mice showed a modest decrease in proteasome function but reached statistical significance only for trypsin-like activity (Figure 4 upper panel).
In our study the protein was expressed lowly at stage I, increased during stage II and showed a modest decrease in stage III.
The fourth gene, RAP2A, showed a modest decrease in expression in the LMNA E161K mutant heart relative to the LMNA normal cardiomyopathic heart, but to a lesser magnitude than the microarray results.
In the other organs, there was no statistically significant difference in IRBC accumulation (Figure S8) except for the spleen, where the IFN-γ−/− mice showed a modest decrease in parasite biomass on day 8 (Figure 5E).
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Mr. Hinesley's statistics show a modest decrease in the median sales price in late 2007 and early 2008 (dropping to $250,000), but a rebound over the last four months to $283,000.
In contrast, mutation of Tyr100A and Asp100C show a modest decrease in the IC50 (table 4) consistent with a slightly increased affinity for gp120 (table 3).
Cx36 shRNA treated cells also show a modest decrease in the number of O4 positive cells yet this did reach statistical significance (Figure 4B).
Keller and Kneissel have shown a modest decrease in Sost transcription in response to a similar dose of ionomycin [43], but they measured Sost levels after 24 hours of ionomycin treatment (rather than 3 hours, as in the study herein).
There is a tendency for pathological responders to show a modest decrease in CD105 staining, whereas nonresponders show an increase.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com