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Importantly, we showed a continuous relationship between missed doses and growth.
Here, too, secondary analyses showed a continuous relationship between the risk of microvascular complications and glycemia extending into the normal range of A1C, with no glycemic threshold.
In addition, a meta-analysis of prospective studies showed a continuous relationship between baseline fasting glucose and subsequent cardiovascular risk (10).
Furthermore, Waikar et al. [ 14] showed a continuous relationship between lower sNa and higher mortality in the HD population without residual renal function, indicating that this relationship is independent of ADH secretion related to underlying disease.
In the 33-year follow-up of the Whitehall study, glucose levels measured 2 h after 50 g oral glucose showed a continuous relationship with coronary mortality beginning at 83 mg/dL; mortality increased 22% for every 18 mg/dL increase up to 200 mg/dL (60), leading to the notion of "a continuum of dysglycemia".
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Alternatively, some measures might show a continuous relationship, with measure 1 continually increasing as measure 2 increases.
An important principle in the analysis of this 20q amplification is that a threshold value can be (arbitrarily) set, but the logistic regression shows a continuous relationship between the aCGH measurement and the risk of a liver metastasis.
The primary HAPO results showed a continuous positive relationship between glucose concentrations during a 2-h 75-g oral glucose tolerance test (OGTT) and the primary outcomes of birth weight >90th percentile, primary cesarean section, neonatal hypoglycemia, and cord serum C-peptide >90th percentile (4).
The HAPO study showed a continuous and graded relationship between maternal glycemia and adverse fetal outcomes.
The 'Hyperglycemia and Adverse Pregnancy Outcome Study' (HAPO), showed a continuous and graded relationship between maternal hyperglycaemia and the risk for an adverse perinatal outcome, independent of other risk factors [ 2].
All other parameters showed a continuous distribution.
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