Sentence examples for show weak affinity from inspiring English sources

However, as interactions between the isolated SH3 domain and a selected set of ligands show weak affinity and low specificity, it is not clear how srGAPs are precisely recruited to their signaling sites.

Experimental studies indicate that under molecular crowding conditions (in the presence of 40 wt% PEG 200), 1 2 show weak affinity for c-myc, while 3 still displays high affinity and selectivity for c-myc.

Thus, we expected this state to show weak affinity for the K-helix.

Neurotrophins also show weak affinity towards the p75 neurotrophin receptor (p75NTR) owing to structural similarities with the Trk family receptors [ 57].

It has been known that Cl− anions show weaker affinity to a titanium atom in an aqueous solution than NO3− and CH3COO− anions do [16].

Moreover, PEG-modified bismuth NPs showed weak affinity to proteins present on the cell surface, and therefore, most of Bi-PEG nanoparticles are expelled outside the cell membrane.

Subsite map determined by kinetic analysis of rAaBGL1 for cellooligosaccharides hydrolysis, using the method for subsite analysis of exo-acting enzyme (Hiromi et al. 1973), revealed that AaBGL1 had the subsite +2 like other GH family 3 BGLs, but subsite map for laminarioligosaccharides, showed weak affinity at subsite +2 (Figure 6).

Alternatively spliced exons are often preceded by a weak polypyrimidine stretch (interrupted by purines) that shows weak affinity for U2AF65.

Cross affinity testing of peptide-phages PP1 6 against all KDM1 and -4 proteins revealed that most phages were specific binders (SI Table S2); however, PP5 displayed some affinity toward KDM1A, and PP3 showed weak affinity for several proteins.

Magnetic circular dichroism (MCD) spectroscopy on CytC3, which catalyzes the double chlorination of L-2-aminobutyric acid, reveals that the 2-His-Fe(II) binding site shows weak affinity for Fe(II) compared to the facial triad with an additional carboxylate; The metal will only bind in the presence of α-KG as an additional ligand [22].

Again, the association between the two proteins, unliganded TR DL and GATA2-Zf, showed weaker affinity for GATA-RE, suggesting again that unliganded TR DL may disturb the GATA2-Zf binding to GATA-RE.