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Most PLA2s do not show this profile and the authors suggest that the enzymatic activity is not responsible for the cytotoxic effect and other mechanisms must be involved.
The increased expression of EGFR is mainly found in head and neck cancers, in which 70-90% of the cases show this profile [ 15].
The results show a good correlation between genes downregulated in the cspC mutant with induction at stationary phase and by carbon starvation, but the upregulated genes do not show this profile.
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Moreover, because the hotspot profile of the 21- and 22-nt PLMVd-sRNAs is very similar (Fig. 5 and data not shown), this profile does not seem imposed by the specific DCLs involved but rather by their RNA substrates.
Indeed, in 24 infection assays performed, 17 showed this profile.
(Two of these patients showed this profile in both their primary tumor and metastases).
Pathway analysis showed this profile is enriched for genes predicted to function in cell signalling, small molecule biochemistry and metabolism.
Taken together, a total of eight patients showed this profile of reduced E-cadherin and positive Snail expression in either the primary tumour (n=5) or metastases (n=5).
The Alexandrium signature abundance data show this same classic profile, and other recent work using SAGE and MPSS has confirms the generality of this abundance pattern.
However, none of the probe sets showed this ideal profile.
Ion trajectory simulations showed this voltage profile yields lossless ion transmission in either of the two directions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com