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However, other studies failed to show such effect [18], [19].
This is the first study to show such effect.
Premarin, which is a conjugated estrogen for the replacement of hormone of postmenopausal women, did not show such effect.
This effect appears unrelated to a general reduction of protein synthesis, since NAMI-A never did show such effect on the treated cells (Bergamo et al, 1999).
Finally, HIF-1α overexpression led to marked reduction of ADR-induced p53AIP1-luc activity in RKO cells, while the HIF-1α-DN mutant did not show such effect, as also tested by in vivo by RT-PCR analyses.
Indeed, a lower cell death rate was observed by blocking miR-34a or miR-146a activity, while miR-21 knockdown did not show such effect and, conversely, promoted apoptosis.
Similar(52)
"Yes, the negative incentive is there, but the data show such effects to be small or non-existent" should not be the full scope of our response.
However, treatment of the cells with the same concentration of palmitic acid did not show such effects.
The induction of GFP did not show such effects in GFP #1.
Other inhibitors of the mitochondrial respiration chain, as well as piceatannol, did not show such effects.
Interestingly, TAM67 further decreased the phosphorylation of Akt at 5 20 μ M of LY294002, whereas TAM67 alone did not show such effects.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com