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During the past three decades, controlled clinical trials of systemically administered adjuvant chemotherapy have consistently failed to show significant benefit in patients with glioblastoma multiforme.
Participants in the Lilly trial also failed to show significant benefit in two other important cognitive tests—a result which "warrants some caution in drawing firm conclusions from these analyses," the company acknowledged in a statement.
U.S. drug company Eli Lilly said on Monday an experimental lung cancer drug developed in partnership with U.S. biotech Isis Pharmaceuticals, exploiting so-called "antisense" technology, had failed to show significant benefit when used in combination with chemotherapy.
Corrosion inhibitor and other additives in deicers did not show significant benefit in inhibiting the strength or chemical changes of concrete induced by cations and/or anions in deicers.
Clinical trials investigating the efficacy of aprepitant in depression did not show significant benefit in safe, non-toxic doses leading to interruption of development and approval of NKR1-antagonists for this indication [26].
These preliminary results are encouraging, although a second study failed to show significant benefit.
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Both trials failed to show significant benefits over placebo in either measure.
The presented results show significant benefits for operators, as well as reduction in the total radiated power.
Palliative chemotherapy does not show significant benefits, as survival rates remain low [ 4].
A large randomized clinical trial [ 8] did not show significant benefits of surgery compared to conservative medical treatment.
Sadly, vitamin D as a therapy has yet to show significant benefits as a treatment for autoimmune disease [ 10].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com