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Licensed therapeutics for the treatment of other viral infections, such as IFN-α2b and ribavirin (used for the treatment of, for example, hepatitis B and C virus) did not show prophylactic or therapeutic value for the treatment of EBOV [ 73, 74].
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Table 7 shows prophylactic drugs with levels of recommendation I and II.
The lead mAb CR6261 showed prophylactic and therapeutic efficacy in mouse models with H5N1 or H1N1 challenge.
Laffey and colleagues showed prophylactic and therapeutic roles of hypercapnia on oxygenation, inflammation, and immunological outcomes [ 12].
Up until now, several large retrospective studies reported contrasting results; however, all showed prophylactic clipping to be beneficial for preventing the delayed bleeding due to endoscopic resections [ 24– 27].
We also show the prophylactic effectiveness and safety of the inclusion criteria.
In this systematic review, we show that prophylactic dosages of dalteparin and tinzaparin did not accumulate in patients with renal insufficiency, while prophylactic dosages of enoxaparin, bemiparin, and certoparin did accumulate.
In this systematic review, we show that prophylactic dosages of tinzaparin and dalteparin are likely to be safe in patients with renal insufficiency and do not need dose reduction based on the absence of accumulation.
However, while antiepileptic drugs can prevent early PTS, clinical studies have failed to show that prophylactic use of antiepileptic drugs prevents the development of PTE.
These studies show that prophylactic use of bone chips impregnated with antibiotics can be effective.
For example, elevated preoperative plasma fibrinogen is associated with increased mortality post-CABG, although recent data show that prophylactic fibrinogen concentrate pre-CABG improves outcomes.
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