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Other studies have failed to show prognostic values of LRP immunoreactivity in acute leukaemia (Damiani et al, 1998; Leith et al, 1999) and ovarian carcinoma (Arts et al, 1999).
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Conclusions Our studied did not show prognostic value with low levels of serum IgG within 24 hours from SS or SSh onset.
Several biomarkers have failed to show prognostic value when externally validated in an independent cohort.
CD10 and Bcl-6 did not show prognostic value in EFS.
Although the aforementioned biomarkers show prognostic value in univariate analysis, the independence of their prognostic value cannot be confirmed in multivariate analysis.
This system was subsequently shown to have good inter-observer concordance, but did not show prognostic value for outcome on further study (Frappaz et al, 2000).
Intriguingly, signatures characterizing tumor microenvironment (Hypoxia and Wound-Response) showed prognostic values for ER-negative breast cancer.
A recent review summarized that Ki-67 expression assayed by IHC showed prognostic values in 15 studies where a total of more than 5000 tumor samples were analyzed [ 24].
Glucose metabolic activity measured by [18F]-fluoro-2-deoxy-glucose positron emission tomography (FDG-PET) has shown prognostic value in multiple malignancies, but results are often confounded by the inclusion of patients with various disease stages and undergoing various therapies.
50, 51 Low TS expression from pretherapeutic biopsies showed prognostic value with respect to impaired CSS.
HER2 amplification showed prognostic value in subgroups of patients, as well as Topo2a.
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