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If men show less benefit from current self-management interventions, there is a clear case for the development of tailored interventions that better meet their needs.
This would potentially bias the results to underestimate the effects of treatment if (as recent results suggest) such patients show less benefit than those treated earlier in the natural course.
Previous work has shown that estimates of benefit derived by reviews which included only randomized trials show less benefit than those from reviews which included less rigorous study designs [ 14].
The degree of effectiveness of biologic therapy treatments in clinical practice in the community, however, has not been established, but effectiveness studies often show less benefit than efficacy studies.
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There's been some effort to get people to buy defibrillators for their homes as well, but studies have shown less benefit to having them.
Subsequent studies with long-acting octreotide analogues have shown less benefit (Raderer et al, 2000; Samonakis et al, 2002) or no benefit (Yuen et al, 2002).
The present study found that the middle-aged women carriers of the Met allele showed less benefit on tasks that demand executive functions and cognitive flexibility.
For example, outpatient exercise training with two or three weekly sessions for 4 weeks showed less benefit than similar training for 7 weeks [ 8- 10].
Laquinimod 1.0 mg showed less benefit (26.7% remission (CI 14%to4444%) and 53.3% response 70 (CI 36%to7070%)), and no effect was noted on remission/response at higher doses.
A similar effect was seen in the first multicountry study where universities with a problem-based curriculum showed less benefit from a short intervention course than those without a problem-based curriculum [ 4].
It was concluded that antiviral therapy using AZT/IFN was the gold standard for the leukemic subtypes of ATL, although patients with the lymphoma type showed less benefit from antiviral therapy than from combination chemotherapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com