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Moreover, from the present work it is observed that the isopropyl substitution did not show improved activity than compared to the n-alkyl substitution.
Although the new substances do not show improved activity when compared to the parent compounds, some useful information has been obtained to understand structure activity relationships.
The resulting compounds (e.g., 7, 8, 14, 30a, and 32b) are highly potent in vitro, and show improved activity in human plasma-based thrombin generation assay.
Afterwards the modified electrodes were tested for the reduction of benzylbromide in acetonitrile solutions by using CV and were found to show improved activity compared to bulk Ag electrode.
It is hoped that these agents will show improved activity, decreased toxicity or set a benchmark as second or third line therapy.
Some of the P450 variants (redder rows) tend to show improved activity on most substrates, while others (bluer rows) tend to show decreased activity on most substrates.
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The most potent antispasmodic dithiobenzanilide 19 showed improved activity with an IC50 value of 0.4 μM.
Compounds 2 showed improved activity and selectivity to T. b. brucei when compared to the lead compound.
Conversely, the conformationally constrained thienopyrimidinone analogs (18a g) showed improved activity in MCH-1R and selectivity over 5HT2C.
The 4″-carbamate analogs retained excellent activity against erythromycin-susceptible Staphylococcus pneumoniae and showed improved activity against erythromycin-resistant Staphylococcus pneumoniae.
The subjection to cell's temperature from 298 K to 343 K showed improved activity and was found stable above 323 K.
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