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Here, we report a series of benzo[e]isoindole-1,3-dione derivatives as selective GSK-3β inhibitors by rational-design and synthesis, which show high selectivity against GSK-3β over Cyclin-dependent kinase 2 (CDK2), and significantly activate the cellular Wnt/β-catenin pathway.
All catalysts show high selectivity to d-sorbitol (>98%).
They show high selectivity to the MAO-B isoenzyme, with IC50 values in the nanomolar range.
The modified SAMs electrodes show high selectivity, sensitivity, reproducibility and stability.
Supported gold catalysts were found in the literature to show high selectivity of 1,3-butadiene hydrogenation to butenes.
Notably, the surface engineered quantum dot hydrogel show high selectivity toward lactate over common metal ions, amino acids and other small molecules that widely coexist in biological system.
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The resultant pharmacophore was, however, weighted towards the class I antagonists, as they show higher selectivity and affinity than other antagonists.
It showed high selectivity for the (R -products and high R -productstes.
FEPO showed high selectivity and high sensitivity for H2S.
The sensor showed high selectivity and sensitivity in aqueous system.
The imprinted film showed high selectivity towards to dimethoate.
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