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On a more granular level, intratumoral drug delivery can vary due to regional differences in blood flow and oxygen levels and/or individual cells can show different sensitivities, so that drugs may only ablate specific subpopulations of tumor cells, allowing other cells to continue to grow, spread and further evolve.
The four scenarios did show different sensitivities to alcohol.
However, as discussed earlier climate models show different sensitivities and it is unclear whether this result is unique to the CSIRO climate model.
The average values of actual DFs of the mode-beams calculated using Eq. (32) are shown in Fig. 14 (dotted lines), in which the different mode-beams show different sensitivities to errors at this level of errors.
We also tested human primary HUVEC cells which arrested with an (IC50 of 30 nM), indicating that different cell types show different sensitivities.
The different genetic background also can have a large effect on physiological processes, since different mouse strains show different sensitivities to neurodegenerative influences (see [24] for a discussion of genetic background effects).
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To address the basis for this difference, we investigated whether Drosophila p53 mutant cells show different sensitivity to killing by maytansinol than do wild-type cells.
This example clearly illustrates that different regions show different sensitivity in different distortion types.
The simulation results show different sensitivity for each flow pattern: for stratified regime, TRFLC and for annular regime, concave and helical shapes were more sensitive.
The same strains also show different sensitivity to oxidative stress with hydrogen peroxide (data not shown).
3) High-risk and low-risk patients might show different sensitivity to precipitating factors and interventions.
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Justyna Jupowicz-Kozak
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