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Finally, we need to test whether the few genes that show consistent changes across studies are those most likely involved in trait variation.
Furthermore, cultured neurons treated with the antipsychotic, clozapine ("-FGF2+VA+Clz" in Fig. 1B), did not show consistent changes in Gad1 mRNA, or Gad1-associated H3K4me3 and H3K27me3.
In our study, endothelial activation markers did not show consistent changes during treatment with bosentan.
Expression of the key enzymes in this pathway did not show consistent changes at either transcript or protein level.
All other variables examined including resting heart rate, heart rate variability or psychometric questionnaires do not show consistent changes before sickness.
In our study, REDD1 expression did not show consistent changes; however, REDD2 expression increased significantly in the DX group compared to the control group.
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Nevertheless, some metabolites showed consistent changes, especially raffinose and uridine.
Comparison between laboratory and field data shows consistent changes in electrical signatures due to iron corrosion and secondary mineral precipitation.
IL-6, which showed consistent changes as a result of both marathon and half-marathon running, has previously been shown to play a role in the regulation of acute phase response, hematopoiesis, and tissue regeneration [12].
Therefore, we focused on the genes that showed consistent changes in response to food deprivation in both sets of mice (comparisons 3 and 4 combined), since there are hardly any differences between the data for the two genotypes (see below).
We identified DRAK2 as showing consistent changes in expression.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com