Result of in vitro drug release study (USP Type-II, paddle method) carried out in two different pH media (pH 1.2 and pH 7.4) showed a triphasic drug release pattern in all the formulations.
The NPs showed a triphasic in-vitro drug release pattern.
Careful analyses of the cumulative mortality curves reported by Lopez-Delgado and colleagues or by our group [ 3] revealed a triphasic pattern.
At the level of HV, this counteraction is responsible for reversal of the venous A-wave, leading to a triphasic pattern of HV Doppler waves in PE [ 26].
Finally, [ 2, 8] and [ 23] all reported a triphasic pattern of calcium decay with an initial fast drop followed by a plateau, and then a relatively fast drop again.
A triphasic pattern of depression, facilitation, and depression is characteristic of paired pulse responses in the dentate gyrus and results from the influence of temporally successive and overlapping phenomena including recurrent inhibition, presynaptic facilitation, and feedforward inhibition.
In BMS, long-term angiographic luminal responses were a triphasic pattern that consisted of a restenosis phase at the early period for 6 months, a regression phase at the intermediate period between 6 months and 3 years, and a late renarrowing phase after 4 years [ 10].
On Doppler US, normal hepatic vein shows a triphasic waveform, consisting of a hepatopetal (coming towards the liver) phase occurring during atrial systole and two hepatofugal phases related to atrial and ventricular diastole.
In the absence of vascular injury, the spectral Doppler analysis normally shows a triphasic waveform over each cardiac cycle, representing the blood acceleration during systole: an early diastolic flow reversal caused by the closure of the aortic valve; and a late anterograde diastolic flow related with the elasticity of the arterial wall, peripheral resistance, and transmural gradient.
Surprisingly, starved nonreplicating mycobacterial cultures showed a triphasic concentration-kill curve (Fig. 1B, −Cm).
