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Finally, Western blotting did not show a substantial effect of INC280 on constitutive Akt phosphorylation and only a minor impact on ERK phosphorylation in VSMCs.
Gene expression experiments failed to show a substantial effect of ABA on any of the OryR-dependent flagellar and chemotaxis genes we tested.
First, the RUM research, although forming the majority of ATM research, is yet to show a substantial effect in improving the drug utilisation patterns.
The preliminary results presented at the Annual Meeting of the American Academy of Orthopedic Surgeons in 2012 did not show a substantial effect of the intervention on functional improvement.
Pharmacodynamic analysis did not show a substantial effect on expression of Ki-67, p27kip1, phosphorylated mitogen-activated protein kinase, phosphorylated Akt and EGFR, and serum levels of sVEGFR-2, VEGF-C and VEGF-D remained unchanged.
The detectable clinically relevant threshold was set at 30%, and the choice was based on the consideration that bone quality in revision surgery is highly variable; an experimental study must therefore show a substantial effect before being clinically relevant.
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The age showed a substantial effect on the growth enhancement in such a way that the younger the age greater the effect.
The isothermal calorimetry shows a substantial effect of the heat of wetting on the total heat evolved, ranging from 10 J/g for lime to 3.9 J/g for ceramic.
This study showed a substantial effect when axial weight was applied only from the proximal bone end, which is the practical effect of a weight-bearing platform.
Although one candidate BSV has shown a substantial effect on parasite densities [20], the assumption that this effect is a constant over different parasite densities in different epidemiological contexts is clearly a simplification.
This study showed a substantial effect on people's knowledge.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com