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The data generated through this method allows predictions of function to be made for previously uncharacterized genes based on the observation that genes with similar function often show a common expression pattern.
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To increase the likelihood to identify HCV-modulated genes, we selected probes showing a common expression pattern in both 1 and 2 datasets.
Previous expression profiling that was conducted with small patient numbers showed a common gene expression signature and reduced number of differentially expressed genes between IGVH subtypes [ 7, 8].
Of these, 69 genes showed a common pattern of expression in the chronic active and acute plaque tissues investigated (Pvalue<0.0001, ρ=0.73, by Spearman's ρ analysis); while 70 transcripts were uniquely differentially expressed (≥1.5-fold) in either acute or chronic active tissues.
All of the probe sets representing amebic RENTs showed a common pattern of expression during L-cysteine deprivation.
Some research groups failed to demonstrate MDR-1 expression in PDAC tissues, whereas other studies showed a common and high MDR-1 expression potentially contributing to the chemoresistant biology of PDAC [ 5, 18– 218.
All of them showed a common pattern, with higher and similar expression values in the cultivars 'Red Candem', '86-6' and 'Sunraycer', almost undetectable expression in 'Rose Diamond' and 'Big Top', and intermediate values in the remaining five cultivars.
(This is quite a common expression of prejudice against lower-caste Christians in Pakistan).
To 'hand someone his head' is a common expression, not normally associated with actual violence.
"No money, no mission" is a common expression in the field.
In Los Angeles, there's a common expression.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com