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The immediate use of an HIV vaccine with reduced VE in high risk communities appears desirable over a short time line but higher VE should be the pursued to achieve strong long-term impact.
In addition, VE should be set up to ensure minimal adaptation costs if changing labour market circumstances force workers to resort to occupations that are further removed from the specific occupations for which they were trained.
Maximal VE should be seen during the influenza season.
33 If this assumption is correct, VE should be lowest in the oldest subgroup.
VE should ideally be measured using influenza-specific outcomes in each of the databases.
Specificity of outcome measure: VE should be greatest for the most specific outcome (laboratory-confirmed influenza infection) and lowest for the less-specific outcomes (all-cause mortality).
Severity of influenza season: VE should be greater in years during which the circulating virus caused a large excess mortality during the influenza season.
Vaccine match: VE should be lower in years during which the influenza vaccine was a poor match for the circulating virus.
Furthermore, besides being less accurate, precise and practical for clinical use, multi-observer VE should not be used as a criterion standard method for the DIA validation purposes, because of its greater uncertainty level compared to that of DIA or count-based methods.
Only you should do what we' ve talked about, she says.
VE is subject to the eternal question of how broad the education programmes offered should be.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com