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Replication of ONYX-015 should therefore be restricted to p53 deficient cells resulting in selective destruction of cancer cells.
This is of great clinical importance as a futile I treatment is costly and not without short- and long-term side effects and should therefore be restricted to those who will likely to benefit from this treatment.
However, the majority of investigators were in complete agreement in that intravenous cytokine administration may cause severe toxicity and should therefore be restricted to a subset of patients with excellent performance status.
Similar(57)
The term stress or stressor should therefore not be restricted to psychological events but, rather, should be viewed in an ample physiological context.
Furthermore, programs to prevent substance use should therefore not be restricted to adolescents only but also extend to pupils in elementary school.
The use of fluoroquinolones for food production animals should therefore be discontinued or at least severely restricted as quickly as possible.
Restrictions should therefore be introduced with caution.
They should therefore be constitutional.
Its evaluation should therefore be respected.
Resulting performance should therefore be markedly worse.
It should therefore be estimated carefully.
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