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These techniques and results should prove relevant to development of future applications of optical fibers in stimulating retinal cells such as (but not limited to) studies of the directional and spatial dependence of light capture, light guiding properties of retinal rods, polarization effects.
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The distinctive gene regulatory information that the results describe should prove more robust and biologically relevant than a signature gene list.
Strategies that block tumor cell interaction with the sub-mesothelial ECM (rather than the mesothelium itself) should prove more effective in blocking intraperitoneal metastatic dissemination at clinically relevant disease stages since cancer cells preferentially adhere to exposed peritoneal ECM.
This should prove useful in guiding protein engineering and mutations to the most relevant parts of a protein.
Therefore, it should prove useful as a new tool to image the subcellular distribution of relevant markers or to localize rare positive cells, like CSCs, within tumour spheres.
The easily monitored, clinically relevant endpoints provide a convenient means for examining ileus in a mouse model and should prove useful for analysis of potential intervention strategies and mechanistic investigations of ileus.
CDCOCA should prove to be a powerful tool for defining mutual associations at gene level and to gain insights into cellular mechanisms relevant for oncogenesis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com