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This study illustrates the potential of design of experiments methods for evaluating computational mechanobiological model parameters and suggests that further experiments should preferably focus at establishing values of parameters related to cartilage formation and degradation.
Furthermore, the use of patient satisfaction research for quality improvement initiatives should preferably focus on the low scoring subgroups of patients while maintaining the high scores.
The clustering of risk behaviours suggests that interventions should preferably focus on multiple risk behaviours simultaneously rather than on separate risk behaviours in order to lessen the burden on public health services [ 17, 18].
Since COF-VAP has a low overall incidence (15 out of 6500 ICU admissions [0.23 %]) and VAP incidences decline [ 45, 48], future research should preferably focus on multi-centre trials.
To gain better insight on organizational factors influencing health care quality, it has been suggested that studies should preferably focus on factors on different levels (e.g. organizational as well as team), include patient outcomes and use multi level data analyses to correct for clustering effects [ 38].
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Efficacy endpoints should be confirmed in larger clinical trials, preferably including newer biological agents and again preferably focusing on specific esophagogastric sites to omit different possible post-operative morbidity and mortality rates [ 26, 27].
Future research should preferably combine quantitative and qualitative methods, focus on possible mediating or moderating factors and explore the use of instruments more sensitive to measure such complex constructs in small office-based practices.
Future studies focusing on these treatments should preferably use a prospective randomized setting and compare the new approach to the gold standard of two-stage exchange arthroplasty.
The management of tile-drained agricultural land to reduce NO3-N losses should focus explicitly on flow events and, more specifically, active management should preferably be conducted in the winter season for discharge events after snowmelt, after heavy rain storms and when the soil moisture conditions are wet.
This may represent a particular focus for both preventive and interventional actions, which should preferably be developed through and in conjunction with the supervising staff.
Exercise should preferably be performed at low intensity and high frequency, within the pain threshold, and focusing on eccentric training.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com