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Although it can be argued that patients may not always be able to distinguish between symptoms, signs, safety events and ADRs, this should not matter unduly, provided that AEs and ADRs are distinguished and appropriately interpreted.
Mathematically, and rationally, this should not matter.
Of course accents should not matter.
Their background or ethnicity should not matter.
Peter H. Schuck, a Yale law professor, said that should not matter.
But the bottom line is: marital status should not matter.
In which case, the current hullabaloo should not matter.
"It should not matter what political stripe you're from.
The colour of his skin should not matter.
"Whether you wear a scarf should not matter".
Meaning, that race should not matter in comedy.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com