Sentence examples for should destabilize from inspiring English sources

From this small set of residues, a crude, but fast free energy estimator [2] was used to check substitutions which should destabilize the dimer while not destabilizing the monomer.

We hypothesized that the bulky residues should destabilize the closed conformation and eliminate the ∼3 kcal/mol energy barrier to TM domain opening and the ∼2 kcal/mol energy difference between the closed and open states, thus oversensitizing the receptor.

Such a deletion should destabilize the dimer interface sufficiently to make monomeric IDE the predominant form in solution.

Conversely, the Erk signal should destabilize the ground state to promote lineage specification.

In contrast, when dA/dT is the pBP, the ordered water molecules are located just above the C atoms of the pBP and should destabilize the ternary complex.

Robetta predicts that substitution of these residues with alanine should destabilize the dimer by at least 1 kcal/mol (Table S2 of the Supporting Information).

"This should further destabilize the Colombo family's command and control".

A war in Iraq should not destabilize the international financial system, which has already taken major steps to manage risks and deal with external shocks, the incoming head of the Bank for International Settlements said Monday.

It is important to emphasize that pin or wire removal should not destabilize the frame construct as this will result in increased movement at the fixator pin bone interface of the remaining pins and wires, initiating loosening and infection of the remaining pins [3, 14].

A threshold of 1,6 kcal/mol was considered, as it corresponds to twice the standard deviation calculated with FoldX and values above this threshold should significantly destabilize a protein [19].

The Q662A substitution strongly enhances dimerization, decreasing Kd by 36-fold (ΔΔ G = −2.1 kcal/mol), although Robetta predicts that this mutation should moderately destabilize dimerization by ∼0.5 kcal/mol (Table S3 of the Supporting Information).