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"But his great track record over the years should be validation enough".
We do not have evidence that the model does poorly in these conditions, but there should be validation of the model (and possibly refinement) with additional empirical studies.
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The next step in pharmacogenetic research should be the validation of these findings in randomised prospective trials, specifically designed to compare the outcome of treatment selected on the basis of patient's genotype versus standard approach.
Validation activities should be planned in a validation plan, in an orderly manner.
All method validation data should be summarized in a validation summary or report.
It is generally accepted that pathology is the gold standard and should be used for validation of tumour delineation methods.
Also, in regard to the newly emerging field of research, more comparable studies should be done for validation purposes.
Secondly, each subset data should be as a validation set, while the rest of the K-1 subsets data as a training set.
Ultimate evaluation of the method should be based on validation.
Intra-run accuracy should be established during validation at a minimum.
With either of these subcutaneous delivery methods, plasma levels of hormones should be monitored for validation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com