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The effective targeting nodes should be downstream and unique molecules in this pathway.
The identified genes are putatively involved in growth cessation and/or dormancy entrance and should be downstream of EVG in this pathway.
To determine how caveolae might participate in ERK signaling, we reasoned that the role of caveolae should be downstream of ras because ras participates in both ERK and Akt activation.
Given the prominent role that caspase-8 plays in the dermatitis, it would be expected that if the intrinsic apoptosis pathway is engaged it should be downstream of caspase-8 and require cleavage of the BH3 protein, BID (Czabotar et al., 2014).
These models will not be nearly as biased by prior information, because both the allele association and gene expression data will be gathered globally, without focusing on what 'should be' downstream of each effect.
The oxygenator should be located downstream of the pump and permit gas exchange by artificially reproducing the function of the alveolar capillary membrane.
A complete border shutdown might have been easier, but Egypt has made sure that there should be no downstream impact, no loss of traffic in countries further down the cables.
Thanks to Ludwig my first paper got accepted! The editor wrote me that my manuscript was well-written
Listya Utami K.
PhD Student in Biology, Bandung Institute of Technology, Indonesia