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For a cancer target to be justified, its inhibition must not only eradicate cancer cells, but should also be tolerated on the cellular and physiological levels.
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These were not observed following the direct intratumoural injection of this chemical, and it should also be noted that the dose used was tolerated systemically over a prolonged period of time.
As a robust industrial biocatalyst, thermostability and operational stability should also be high enough to tolerate rigorous reaction conditions.
However, it should also be emphasized that not all patients tolerating well a STR will be certainly less adherent or will interrupt treatment after switching to a regimen with the same drugs, not co-formulated.
It should also be effective in patients with treatment resistance symptoms, in whom the only currently available option is clozapine, which is poorly tolerated (Mortimer, personal communication).
Also, acts of physical assault should not be tolerated and should be punished among young people.
It is also worth noting that although unjust enrichment from crime should not be tolerated, it has little if anything to do with reparation.
I also agree with education historian Diane Ravitch who recently wrote: "Yes, cheating is wrong and should never be tolerated, but this punishment does not fit the crime.
This should not be tolerated.
"It shouldn't be tolerated.
Illegal immigration should not be tolerated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com