The GRMD clinical and histopathological phenotype resembles DMD: typically elevated serum CK activity is detectable shortly after birth, weakness is evident within the first few weeks and joint contractures significantly impair movement by 6 months.
Endomembrane asymmetry is detectable shortly after photolocalization of a cortical patch of actin at the rhizoid pole [ 15].
OS as measured by mitochondrial redox ratio (NADH/FAD) was detectable shortly after the onset of diabetes and further increased with the duration of diabetes.
Elevations of TP and globulin concentrations plus decline in A/G ratio were detectable shortly after seroconversion in SA 4, SA 6, SA 20, and SA 22. Albumin concentration declined within reference range shortly after the beginning of the acute stage in SA 4. SA 20 displayed fluctuating albumin concentrations around the lower limit of the reference range during the whole trial period.
"This is the first study [to show] that illness [is detectable] shortly after onset," she added.
Embryonic GAD67 transcripts reach their maximum during embryonic development and decline to barely detectable levels shortly after birth [13], [19].
Therefore, this study examines parameters which are on one hand detectable during or shortly after treatment, more reliable, and more sensitive than ophthalmoscopic lesion evaluation and which are on the other hand correlated with the long-term lesion size.
It has long been known that proteinuria appears shortly after severe burns, and is detectable for several weeks until patients become critically ill [ 2].
The rapidly detectable effects of levosimendan shortly after the start of infusion into patients with acute heart failure are unlikely the result of hemodynamic improvement.
The activity of the ARR22 promoter was first detectable in the seeds shortly after fertilization (emerging silique) and persisted through all the following developmental stages until the seed was shed.
We allowed for imperfect sensitivity of the assay shortly after transmission by simulating time of detectable infection and allowed the simulations to reflect additional positive test results at the 4 to 8 week visit due to breastfeeding.
