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We showed that 24 h exposure of NALM-6 cells to 1 μℳ JQ1 led to increased replication fork stalling as indicated by shortening specifically of the second label in ongoing forks and a substantial increase in the percentage of stalled replication fork structures.
Although the clinical scenarios that have been proposed to implicate pectoralis minor shortening specifically and muscle imbalance generally are appealing and provide a framework for a clinician to guide the clinical evaluation and basis for treatment in patients with symptoms the available literature at best is supported by equivocal evidence.
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But in some parts of the former Soviet Union where life spans shortened, specifically Belarus, Ukraine and Russia, the reasons were harder to gauge.
Thus, telomerase haploinsufficiency leads to anticipation phenomenon in longevity, which is related to telomere shortening and, specifically, with the proportion of short telomeres.
Recent work by Mukhopadhyay et al. has demonstrated that SENP6 stabilizes kinetochore component CENP-1 by specifically shortening SUMO2/3 chains on CENP-1 and antagonizing RNF4 (Mukhopadhyay et al., 2010).
Low serum calcium levels can also induce arrhythmias (specifically shortening of the electrocardiographic QT interval).
For men, TLC (specifically shortening), but not baseline TL, was related to greater cardiovascular mortality, OR = 3.0 (95% CI: 1.1 - 8.2).
Specifically, shortening LOS may decrease the cost of hospitalization as demonstrated in a recent economic analysis of studies 1 and 2 [ 29].
In this study, we sought to understand how changing the duration of the prevalence period, and specifically shortening it from a "gold standard" of 36 months, would affect the incidence estimates for 12 chronic and acute conditions common among the elderly.
Specifically, shortened telomeres, low telomerase activity, decreased anti-oxidant capacity and increased oxidative stress are correlated with increased psychosocial stress [29] and with increased vulnerability to a variety of disease states [30].
The catching instructor Tony Pena and Manager Joe Girardi have worked with Montero on refining his throwing mechanics, specifically on shortening his release.
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CEO of Professional Science Editing for Scientists @ prosciediting.com