Sentence examples for shortening aging from inspiring English sources

Since the CoQ9 deficit is evident before telomere shortening (18), this supports a role for CoQ9 levels as an early programming mediator of telomere shortening, aging, and disease of the aorta.

Telomeres generally shorten with aging, but the shortening may be accelerated in the presence of chronic psychological stress [ 10].

She also studied the influence of telomere shortening on aging and age-related diseases.

Telomere shortening with aging is another factor that leads to aberrant stem cell functioning, interfering with potential therapeutic designs.

The telomerase, a reverse transcriptase compensates for the telomere loss in those cell types where it is expressed [12] [15], but its level of activity in most adult tissues is not sufficient to counteract telomere shortening with aging [16].

It has been shown that in some tissues cells suffer telomere shortening during aging in humans [ 4, 19- 21].

Given the increase in soma volume and process shortening with aging, the theoretical brain volume a microglial cell could cover (survey) was calculated for the different age groups.

Most of the applications of high throughout telomere length quantification methods are derived from the association between telomere shortening and aging.

This association is supported by the fact that the rate of telomere shortening with aging is accelerated in some premature aging syndromes owe to mutations in telomerase such as some cases of Dyskeratosis congenita (DC) or aplastic anemia [ 48, 49].

It is important to note that telomere shortening in aging subjects has been reported in human peripheral blood leukocytes [ 22, 23], in PBMCs [ 24], and in T cells [ 25, 26].

In the G3 mTerc−/− brains, which suffer from telomere shortening during aging, a decrease in blood vessel laminin, the main component of the basement membrane, and a slight decrease in CD31 protein expressed by endothelial cells were noticed.