The Southern analysis (Fig. 5B), revealed a fragment of pT2-FloxP-PTK likely resulting from the integration of a shortened PTK expression cassette lacking at least one flanking RRS.
Weichert et al (2004) described increased expression of CD166 from normal to tumour tissue, and, in a group of 111 colorectal cancer cases, observed correlation between membranous, but not cytoplasmic, CD166 expression and shortened survival.
Taken together, our data suggest Bif-1 expression as a new prognostic marker for early stage CRC, because patients with reduced Bif-1 expression exhibited shortened survival in stages I and II.
The HMGA2 gene, coding for an architectural transcription factor involved in mesenchymal embryogenesis, is frequently deranged by translocation and/or amplification in mesenchymal tumours, generally leading to over-expression of shortened transcripts and a truncated protein.
Consistent with our previous data, ectopic expression of hnRNP A1 increased Drp1 expression (Fig. 4C), suggesting that over-expression of hnRNP A1 results in shortened mitochondrial length by elevating Drp1 expression in neuroblastoma cells.
By multivariate analysis, low BECN1 expression was significantly associated with shortened survival, even after adjustment for BRCA1 expression, age, tumor grade, tumor size, stage, intrinsic subtypes, TP53 mutation and treatment (hazard ratio 0.6 [0.4–0.9], P = 0.02) (Table 3).
A female Sumatran rhino living in a breeding facility in Way Kambas National Park, Sumatra, gave birth to a baby male rhino calf named Andatu (a combination of his parent's names and a shortened version of the Indonesian expression for "gift of god").
Intriguingly, low EphA1 expression correlated with shortened survival.
Conversely, onartuzumab was associated with shortened PFS in the MET expression-negative setting (P = 0.05).
Finally, CD86 expression correlated with shortened time to first treatment and increased γ-H2AX focus formation.
