Muscle contractile properties derived from architectural-based algorithms may overestimate real forces and underestimate shortening capacity because of simplistic assumptions regarding muscle architecture.
The reduced cardiomyocyte shortening capacity received convincing support from the reduced R-wave height in ECG reading.
The depth of discharge is limited to 50%to80%0% of the overall battery capacity; the depth of discharge represents the fraction of the battery that can be used without damaging the battery through internal irreversible processes, which shorten its capacity and durability.
This in turn raises the question, is shortened cellular replicative capacity a general characteristic of progeroid syndromes?
It is associated with a specific phenotype of excessive erythrocytosis, increased pulmonary ventilation and arterial hypocapnia, pulmonary hypertension, excessive pulmonary vascular and ventilatory responses to hypoxia, early and marked accumulation of lactate during exercise, limited exercise capacity, and shortened life expectancy (16– 16).
Our data demonstrate that hStn1 is essential for long-term viability of normal human fibroblasts and that reducing hStn1 levels dramatically shortens their replicative capacity.
If this is not addressed, sediment loads could exceed normal design parameters in some reservoirs, thus reducing storage capacity and a shortened useful lifespan.
Furthermore, shortened hepatocyte lifespan and impaired capacity for liver regeneration after partial hepatectomy are detected in hepatocytes that do not express RXRα [ 6].
Shortened telomeres limit the regenerative capacity of tissues and are associated with increased age and a variety of medical conditions including Dykeratosis Congenita, aplastic anemia, and pulmonary fibrosis [ 5, 6].
We speculated that the titration of DNA repair proteins to shortened chromosomal ends might decrease repair capacity at bona fide DSB sites.
