Sentence examples for shortened action from inspiring English sources

We found that both ICA-105574 and NS1643 concentration-dependently shortened action potential duration (APD) in ventricular myocytes, and QT/QTc intervals in isolated guinea-pig hearts.

It shortened action potential duration (APD) in isolated rat ventricular myocytes, and increased the threshold current for triggering action potential, but had no effect on the inward rectifier K+ current IK1.

Persistent atrial arrhythmias are associated with ectopic beats [ 6], shortened action potentials [ 1, 7], and high rates of tissue excitation [ 8].

In fact, terfenadine, which also shortened action potential duration in the SCREENIT test system (10 µM [ 23]), has recently been suggested to cause arrhythmias not by a TdP mechanism, but by its strong INa-blocking activity [ 46].

But what may be the net effect of ranolazine on action potential duration in patients with AF with shortened action potential duration (as usually shown in AF)?

In turn, this shortens action membrane potential and prevents influx of Ca2 + and Ca2 + overload, which is cardioprotective [2].

It is traditional view that the activation of KATP channels shortens action membrane potential resulting in decreased influx of Ca2+ and prevention of Ca2+ overload [30].

The chain shortening action of AMSH is consistent with its high selectivity for Lys63-linked chains; it can disassemble Lys63-linked chains but perhaps cannot remove ubiquitin completely from the cargo.

Traditionally, it has been suggested that the opening of sarcolemmal KATP channels shortens action membrane potential, prevent influx of Ca2+ and intracellular Ca2+ overload, which is the main cause of cellular death in metabolic stress [reviewed in 2].

Hyperkalemia reduces the resting membrane potential, slows conduction velocity, increases the rate of depolarization and repolarization due to increased membrane permeability for potassium, and shortens action potential duration [ 42, 45, 46].

Thereby it reducing the amplitude of the myocardial action potential, shortening the action potential duration [ 12], and significantly inhibiting the myocardial sodium [ 6], potassium [ 8] and calcium [ 11] channel function.