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However, the DESR may shorten studies where response rates are low but high EPD rates suggest the ultimate efficacy will be poor.
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It can promote fast screening of potential therapeutic drugs, shorten preclinical studies, and accelerate drug development process.
The decision can be to extend the study because there are fewer positive responses than expected or to shorten the study simply because there are more positive responses than expected.
– Low-carb diets could shorten life, study suggests.
We have avoided such testing because we have noticed that survival appears shortened in studies that perform extensive rotarod and other motor functions tests.
This concerted escalation of dose, and dosing duration, was designed to increase patient accrual and potentially shorten the study duration, while preserving patient safety (Sessa et al, 2007).
These findings match those from chronic stretch-shortening contractions studies, in which skeletal muscle adaptation can occur if the muscle is able to compensate to the increased demands of an activity, but maladaptive changes if the muscle is not able to meet these demands [ 25- 27].
The objective of this analysis was to demonstrate the potential benefits of Bayesian adaptive designs by shortening the study duration and therefore limiting patient exposure to ineffective placebo or an active comparator with a known side effect.
To explore the impact of de novo TERT haploinsufficiency on telomere shortening, we studied a large number of individuals with 5p– syndrome having a TERT gene deletion.
Shortening the study duration needed to answer the specific question of the trial undermines the validity of the results, may mask true treatment effects, and may confound results by introducing a practice effect on test scores.
Jake could not pass up the opportunity to shorten his undergraduate studies by one year and attend one of the world's top graduate schools for international studies.
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