Sentence examples for shorten leading from inspiring English sources

In families that are heterozygous for a mutation in the gene that encodes telomerase, telomeres shorten leading to a distinct disease.

When N d further increases to 1.31 × 1018 cm−3, the τ bulk is further shorten, leading to a lower J sc than that of the case with N d = 4.0 × 1017 cm−3 and a sustaining decrease of V oc.

Consequently, the marketing chain is expected to shorten, leading to more efficient distribution and lower retail prices.

In most normal somatic cells, telomerase is repressed and telomeres progressively shorten, leading to limited proliferative lifespan [ 2, 56].

UV irradiation or other environmental exposures can also lead to telomere damage which induces similar aging processes like telomere shortening leading to a premature aging process.

For instance, it has been shown that the combination of telomerase inhibitors with tankyrase inhibitors enhances telomere shortening, leading to cell death29.

Usually, the net effect is that the time to initiation of active corrosion is shortened, leading to greater localized corrosion and earlier reduction of ultimate capacity and structural stiffness.

The interstitial deposition of proteinaceous material causes a tight ring-like band impeding myocardial fibre shortening, leading to decreased ventricular compliance, thickening of the ventricular wall, diastolic heart failure, restrictive cardiomyopathy and eventual atrophy and systolic failure.

These differences in miR expression may serve as a starting point to explore the genetic changes caused by telomere shortening leading to the above described phenotype of cancer cells.

The increased thickness of the smooth muscle layer could enhance shortening, leading to increased airway narrowing and airflow obstruction [ 1].

The consequence of increased oxidative stress is DNA damage and telomere shortening, leading to reduced matrix production, chondrocyte senescence, and apoptosis [ 73– 73].