Sentence examples for shorten below from inspiring English sources
If the telomeres shorten below a critical length, the cell can no longer divide and eventually dies.
Several generations and a long lag time may be required before telomeres shorten below a critical length [ 62- 64].
A predicted shortcoming of therapeutic strategies based on telomerase inhibition to treat cancer is that they will be effective only when telomeres shorten below a minimum length.
A caveat of therapeutic strategies based on telomerase inhibition to treat cancer is that they will be effective only when telomeres shorten below a minimum length.
Thus, we suggest that as the telomere tracts shorten below a minimal threshold, proteins that bind to double-stranded telomere repeats are lost and the telomere becomes dysfunctional, resulting in recruitment of Mec1p.
8 11 When telomeres shorten below a critical length they lose the functions of the shelterin complex and thus they are recognised as DSBs and activate the DNA damage response pathway (DDR).
In the case of replicative senescence, cells enter G1 arrest after the telomeres have shortened below a critical length [ 29].
Once telomeres have shortened below a preset length, cells activate mechanisms that irreversibly arrest the cell cycle leading to cellular senescence.
Shortening below a specific threshold length results in telomere dysfunction, leading to genomic instability, apoptosis and/or cell senescence, and has thus been implicated in the loss of tissue homeostasis, organ failure and organismal aging (10,11).
Although some chromosome-type meta-TIFs might simply represent the chance occurrence of intermediate-state telomeres on both sister chromatids, some might represent telomeres that have shortened below the absolute length required to form a fully protective structure, so that the probability of forming an intermediate-state telomere is now 100%.
On the homepage, there remains a big URL input box for shortening, and below that, a list of the links you've already shortened (if you're signed in).
